The main objective of this research was to evaluate the ability of different plywoods made of durable heartwood and/or non-durable sapwood to resist termite damage. The well-known durable cypress (Cupressus sempervirens) was chosen for this study. The natural durability of cypress solid wood, divided into sapwood and heartwood, as well as the durability of 17 different laboratory manufactured plywoods, was evaluated towards Reticulitermes santonensis termites. The durability towards termites is discussed by taking into account the influence of composition of the panel (proportion of durable/non durable timber), the ply numbers, the ply thickness, the number of glue lines, and the way of integration of the different plies.