For genetic information and in view as a possible diagnosis method various isolates of the dry rot fungus, Serpula lacrymans, the wild merulius, S. himantioides, and the cellar fungus, Coniophora puteana, from Asia, Europe and USA were investigated by the polymerase chain reaction (PCR) based technique of randomly amplified polymorphic DNA (RAPD). The banding patterns obtained revealed for S. lacrymans a rather species-specific reaction which may used to distinguish the dry rot fungus from other indoor rot species. On the other hand, the isolates of the wild merulius and the cellar fungus showed more polymorphism possibly suitable for identification of special isolates.