The wide-used triazoles alter the biosynthesis of ergosterol leading to a disruption of fungal membrane functions. The aim of this study was to investigate the effects of another cell wall perturbing agent, caffeine, in combination with propiconazole on the growth of wood-decaying fungi. 10 mM caffeine inhibits totally the growth of five fungal species. The obtained results showed that caffeine have an additive effect with propiconazole and Congo red, another cell-wall perturbing agent, on Trametes versicolor growth.