Evaluation of hydroxamates as wood preservatives

IRG/WP 04-30330

P Gérardin, S Dumarçay, E Gelhaye, A Mbamba, V Mussavu

Fungicidal activity of different hydroxamates was investigated by laboratory malt-agar block tests to evaluate their potential as wood preservatives. Results obtained indicate that benzohydroxamic acids substituted or not on the aromatic nuclei were unable to protect wood blocks against the white rot fungus Coriolus versicolor while 2-hydroxypyridine-N-oxide (2-HPNO) possesses an interesting activity. The effect of 2-HPNO was also studied on Poria placenta, a brown rot fungus, and the minimal inhibiting concentrations determined on both rotting fungi. Structure/activity relationships evaluated with different analogs of 2-HPNO as hydroxypyridine (2-HP), 3-hydroxypyridine-N-oxide (3-HPNO) and pyridine N-oxide (PNO) indicated that hydroxamic acid is essential for antifungal activity.


Keywords: Hydroxamate, 2-hydroxypyridine-N-oxide, wood preservation, white rot, brown rot, siderophore

Conference: 04-06-06/10 Ljubljana, Slovenia


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