The efficiency of 2-hydroxypyridine-N-oxide (2-HPNO) as wood preservative has been investigated. As shown using classical experiments as well as using response surface methodology, the efficiency of 2-HPNO as wood preservative is strongly improved in presence a chelator like EDTA and/or of Irganox 1076 an industrial antioxidant. In these conditions, wood preservative efficiency of the mixture the three previous compounds is quite similar to that of tebuconazole used alone. 2-HPNO exhibits an hydroxamic acid function and is a susbtrate of fungal peroxidase. These properties could explain the observed synergy. The implications of these data for the design of new wood preservation strategies are also discussed.

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