Connecting fungal genomic variations to wood chemical composition: A way to understand the adaptation of wood decaying fungi

IRG/WP 12-10776

E Gelhaye, Y Mathieu, E Meux, A Thuillier, M Mélanie

The development of new sequencing methods allows now exploring the detoxication systems of wood-decaying fungi. These systems, called xenome, are mainly composed of oxidative enzymes (phase I) and of conjugation enzymes (phase II). These enzymes belong to superfamilies, which are extended in the plant cell-wall interacting fungi. From different approaches coupling in particular comparative genomic and biochemical and structural protein biochemistry, we develop in this paper the idea that the expanded xenomic network could reflect the adaptation of these wood-decaying fungi to their molecular environment and particularly to the wood chemical composition.

Keywords: agaricomycetes, cytochrome P450 monooxygenases, xenome, glutathione-S-transferases

Conference: 12-05-06/10 Kuala Lumpur, Malaysia

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