This study evaluated the efficacy of five different nanoparticles (zinc-oxide, zinc-borate, silver, copper-oxide, copper-borate) applied with different concentrations against the brown rot Coniophora puteana and the white rot Coriolus versicolor. The generally effective nanoparticle treatments were the combinations containing borate in its chemical structure. However, only zinc-oxide and silver nanoparticles showed good resistance against leaching. Unfortunately, zinc-borate and copper-borate showed low resistance against leaching, as after leaching the treated samples showed similar decay compared to the control. Thus, only zinc-oxide at higher concentration (5 %(m/m)) provided effective protection also after leaching.