Many plant-derived substances have fungitoxic, pecticidal and insecticidal ability. Neem leaves are very popular in this respect since the ancient time. The present study is to investigate the fungitoxic activities of neem leaves extractives against wood decay fungi. Three different solvents, i.e. acetone, methyl alcohol, ethyl alcohol, were used to isolate the extract of neem leaves. The extractives were then used to see the inhibition acitivity over the test fungi in laboratory and natural condition. Both results proved that 3% concentration of acetone extract is best for inhibiting the growth of test fungus. Acetone and methanolic extract was also effective against that decay fungus. From this investigation, it is established that neem extract is potential source of biological preservative of wood and it can be used in any wood related commercial purposes.

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